Background

    Spring and autumn are crucial seasons for preventing the occurrence of animal diseases, serving as key periods to    prevent major outbreaks. Proper animal disease prevention during these seasons can effectively reduce the incidence of animal diseases, benefiting farmers' income growth and agricultural efficiency, ensuring food safety, maintaining public health security, preventing zoonotic diseases, and promoting the healthy and orderly development of animal husbandry. Traditional manual operations are relatively cumbersome with low automation levels, making it impossible to achieve high-throughput testing. In response to this issue, I-omics Biotech has introduced a high-throughput automated disease detection technology for poultry and livestock, aiming to free up labor, improve testing efficiency, and better contribute to the development of animal husbandry.

Details of the programme

The high-throughput automated animal disease detection technology launched by I-omics Biotech is a solution for various detection technologies such as blood coagulation and blood inhibition during spring and autumn prevention. Through automated instruments, the detection efficiency can be increased by 3-5 times, greatly reducing labor costs.

1. Early sample processing system——FluidMaster 130

The Master Liquid Handling series FluidMaster 130 is a multifunctional liquid handling system with an oversized work surface. It can accommodate up to 20 tray positions, allowing for the placement of various functional modules to perform complex liquid handling tasks. This system is ideal for sample pretreatment and addition during spring and autumn prevention periods. The system is easy to operate, stable in operation, and user-friendly. Its greatest advantage is its unattended operation and high degree of automation.

Main functions: ① automatically add samples to the test plate; ② automatically complete the complex addition of various reagents

2.High speed reagent filling system——MD 9608D

MD 9608D The high-speed reagent dispensing system can perform high-throughput automated dispensing of various types of reagents, significantly enhancing work efficiency. The equipment is suitable for liquid dispensing and sample addition of physiological saline, various viral antigens, chicken red blood cells, and other reagents, as well as complex applications such as Elisa experiments. Its greatest advantage is: efficient and rapid liquid dispensing, compact size.

 Main Functions: ① High-precision rapid dispensing of trace volumes; ② Speed: <10 seconds/96-well plate (25ul); <20s/384-well plate (20ul) ③ Dispensing volume range: 1-999uL (small volume pipette set); 5-50000uL (large volume pipette set); ④ Dispensing volume accuracy for 100uL: CV<2%;

3. Multi-component liquid dispensing system——MD 9608F

MD 9608F The multi-component liquid dispensing system integrates four high-precision liquid dispensers into one unit to perform complex multi-component liquid dispensing. It can achieve high-throughput automated dispensing for four different reagents (saline, various viral antigens, chicken red blood cells) without the need to change tubing, significantly enhancing work efficiency. Its greatest advantage is that it can dispense four different reagents simultaneously, making it suitable for experiments requiring multiple reagents.

Main performance: ①4 sets of 8-channel high precision liquid separation channels; ② speed: <10 seconds/96-well plate (25ul); <20s/384-well plate (20ul); ③ 100uL liquid separation volume accuracy: CV<2%.

4.Microplate gradient dilution system—— MDPro 400

The platform is specifically designed for high-throughput system preparation in blood coagulation/inhibition, drug screening, and antibody screening. It features high-throughput automated gradient dilution capabilities and can process 1 to 4 microplates simultaneously, handling over 100 plates per hour, significantly enhancing the efficiency of disease detection in poultry and livestock. Its greatest advantage is the ability to perform gradient dilutions on four plates simultaneously, making it one of the fastest gradient dilution systems globally.

Main performance:① 1-4 microplates of any number of concentrations can be prepared at the same time; ② The average speed of each plate is 15-25 seconds; ③ Range: 5-200ul.

5. Fully automatic blood coagulation imaging analysis system——Smart HA/HI Analyzer

During the spring and autumn prevention periods, a large amount of blood clotting/inhibition test data needs to be analyzed, managed, and stored. The system employs advanced imaging technology to analyze two test plates at once. Combined with an advanced deep self-learning neural network algorithm, it can quickly and accurately analyze blood clotting and inhibition conditions, automatically generating reports. The system completes the imaging and analysis of two plates in just 10-20 seconds, significantly improving work efficiency!

Main performance: ① Automatically complete the whole process of blood coagulation/inhibition test results photography, analysis and report; ② Throughput: 2 detection plates/single imaging; ③ Report speed for a single test: 15-20 seconds; ④ Double detection plate design, which is conducive to improving the reading speed.

practical application

1.For animal disease prevention and control: in spring/fall prevention, high pathogenicity influenza in poultry and livestock was tested by hemagglutination/hemagglutination inhibition to achieve high-throughput detection.

2.For compulsory immunization of diseases in pigs, cattle, sheep and other livestock: during spring/prevention/autumn prevention period, it is necessary to quickly implement the evaluation of animal disease immunity effect, solve the problem of large sample accumulation with high-throughput automation, and improve the experimental efficiency.

3.Pathogen monitoring for animal diseases: In the spring/fall large-scale disease screening, Aiao Biotech launched a comprehensive automated process to greatly improve the efficiency of experiments.