MDNano 4/ MDNano 8 Automatic Microfluidic Dispensing System (NanoUpgrade)

MDNano 4/ MDNano 8 Fully Automated Microfluidic Dispensing System

The MDNano series enables nanoscale precision pipetting of reagent samples, allowing liquid dispensing into 96/384/1536-well microplates for subsequent analyses. These applications include PCR microsystem construction in molecular marker breeding, cell function analysis, compound drug screening, and NGS testing. The instrument features optional 4-or 8-channel high-precision pipetting systems, with each channel capable of independent vertical movement for liquid aspiration or dispensing, enabling high-speed liquid handling. Single dispensing volumes range from 200nl to 250μl. The system also supports precise dispensing of heterogeneous liquids such as suspended microspheres, magnetic beads, and fluorescent microspheres. As the industry's most powerful and fastest nanoscale micro-pipetting platform, it delivers exceptional performance in its field. 

             Performance parameter：

1. The system can perform nanoscale high-speed micro-pipetting and liquid separation on 96/384 orifice plates.

2. Number of separation channels: 4 or 8

3. Liquid volume range：200nl-250μL

4. Liquid volume accuracy：CV≤3.0%，5μL

5. Flexibility：Each channel can move independently up and down

6. Plate capacity: includes 9 microplate wells

7. Suction head cleaning: includes 8 suction head cleaning positions, reusable suction heads, cost saving

8. The suction head loading and unloading: contains a suction head box position and a suction head automatic unloading position

9. Refrigeration module (optional): Operating range: 4℃ to room temperature, suitable for reagent pre-cooling and long-term storage

10. Target plate positions: including 4 target 96/384-well plate positions

11. Reagent plate: contains 3 mother liquor reagent plates

12. Liquid aspiration function: allows each channel to aspirate liquid from any well on the parent plate

13. Splitting function: Allows splitting any liquid into any labeled micropore

14. Third-party docking: Provides a driver command interface to connect with robotic arms or their devices, meeting the requirements of automation platforms

Important applications：

The Breakthrough Value of Innovative Drug R&D

        In the field of innovative drug development, the MDNano system seamlessly integrates into 24-hour automated workflows. Supporting high-throughput screening with 96,384 to 1536-well plates, it automatically completes compound dilution, mixing, and distribution, significantly shortening screening cycles. Its high-precision features ensure reliable data for IC50/EC50 curve determination, providing quality assurance for candidate compound discovery. Drug screening demands extreme precision in liquid handling and throughput. MDNano's nanoscale separation capability enables researchers to obtain more reliable data with fewer samples while supporting continuous flow processing for deep-well plates, accommodating complex drug metabolism pharmacokinetics (DMPK) analysis workflows. Additionally, the system's open API interface allows intelligent integration with LC-MS, detection platforms, and other equipment, establishing a fully automated closed-loop system from sample processing to data analysis.

The Breakthrough Value in the Field of Molecular Breeding

        In modern agricultural biotechnology, the MDNano system provides precision tools for molecular marker-assisted breeding and gene editing. It enables nanoscale dispensing of genomic DNA, PCR reagents, and enzymatic systems, supporting high-throughput genotyping and SNP typing experiments. Its low dead volume design minimizes waste of DNA samples and expensive enzymes, lowering cost barriers for large-scale breeding programs. For high-viscosity reagents common in molecular breeding, MDNano employs active drainage technology to eliminate clogging risks associated with traditional pipetting. The system supports customizable non-standard well formats to meet diverse breeding experiment needs, and when integrated with robotic arms, achieves full-process automation, significantly enhancing breeding efficiency.